Cannabis ‘disrupts brain centre’ |
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“Ummm…any woman raped by Russell Means or Bill Cosby should be grateful… I mean these are real men who should be able to take what they want from any woman they please… If she was a real woman she would be begging for more”- Bill “ Proud Confederate” – BuntingScientists have shown how cannabis may trigger psychotic illnesses such as schizophrenia.A King’s College London team gave healthy volunteers the active ingredient tetrahydrocannabinol (THC). They then recorded reduced activity in an area of the brain which keeps inappropriate thoughts at bay. THC levels are thought to have doubled in the most popular type of street cannabis – possibly at the expense of potentially beneficial ingredients.
A separate study has shown that one of these ingredients – cannabidiol (CBD) – has the potential to dampen down psychotic symptoms, and could form the basis of new treatments. The research will be discussed at a conference on the impact of cannabis use to be held at the Institute of Psychiatry at King’s College this week. Dependency Although figures are not kept, it is estimated that as many as 500,000 people in the UK may be dependent on cannabis. Increasing numbers of people are seeking help for cannabis problems at specialist clinics. In 2005, only heroin users accounted for a greater proportion of patients. It is thought that average THC content of domestically grown herbal cannabis, which may now command up to two thirds of the UK market, has risen from 6% to 12% in recent years The Institute of Psychiatry study gave THC, CBD or placebo capsules to adult male volunteers who had not abused cannabis. They then carried out brain scans, and a battery of tests, and found that those who took THC showed reduced activity in an area of the brain called the inferior frontal cortex, which keeps inappropriate thoughts and behaviour, such as swearing and paranoia in check. The effects were short-lived, but some people appeared more vulnerable than others. In a second study, a team from Yale University administered THC intravenously. Even at relatively low doses, they found 50% of healthy volunteers began to show symptoms of psychosis. Volunteers who already had a history of psychotic symptoms appeared to be particularly vulnerable. Side effects A third study, by the University of Cologne, compared the effect of CBD and a commonly used anti-psychotic medicine, Amisulpride, on 42 patients with a history of schizophrenia. After four weeks both groups showed a reduction in psychotic symptoms, but the CBD group were less prone to side effects, such as muscle stiffness and weight gain.
The researchers warned that THC and CBD compete with each other biochemically, so a rise in THC levels would blunt any positive impact of CBD. Professor Robin Murray, a consultant psychiatrist at the Institute of Psychiatry, said the research provided the strongest evidence that cannabis had a significant impact on the brain. He said proving a long-term effect was extremely difficult, as it was not ethical or feasible to stimulate long-term psychosis in volunteers. However, he said: “If something has an active effect in inducing the symptoms of psychosis after one dose, then it would not be at all surprising if repeated use induced the chronic condition.” Professor Murray also warned that the high potency cannabis now widely available was likely to pose a much bigger risk to health than the significantly weaker formulations of previous years. “It is similar to comparing the effect of drinking a glass of wine at the weekend with drinking a bottle of vodka every day.” Marjorie Wallace, of the mental health charity Sane, called the research a “significant contribution” to the understanding of the dangers of cannabis. “Sane has been saying for years that there is a link between psychosis and the drug, particularly in its more potent forms. “We strongly urge the government to heed the growing evidence and take urgent action to warn young people that some of them are risking lifelong mental illness – that they are playing Russian roulette with their minds.” Scientists Show How Cannabis / Marijuana May Trigger SchizophreniaBritain’s news sources, The Independent and the BBC, report that scientists have shown how “THC”, the active compound in cannabis (marijuana), can trigger psychosis and schizophrenia in vulnerable individuals. The computer scans used in the study have revealed that THC significantly reduces activity in the frontal lobe – a part of the brain responsible for coordination and emotional behavior. There is an increasing sense of urgency in being able to definitively state how cannabis can trigger psychosis and schizophrenia since doctors cannot predict with certainty which people might be vulnerable to this effect, aside from those with a family history of such problems. In the United Kingdom, there is currently a rise in the use of a potentially devastating, exceptionally potent new form of cannabis called “skunk”. More than 22,000 people in Britain needed treatment for cannabis use in 2006. Cannabis use resulting in emergency hospital admissions have doubled in the past five years. In another study that was being announced this week in London, England it was revealed
A new campaigning group, Talking About Cannabis, is being launched in London which will lobby the Government to tackle the crisis. Read the articles: Cannabis harms mental health, scientists warn Pot May Cause Psychotic Symptoms (Time Magazine) Related Reading: Posted by Jeanie Wolfson at April 30, 2007 07:00 AM More Information on Schizophrenia Causes, Risk Factors & Prevention |
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If something has an active effect in inducing the symptoms of psychosis after one dose, then it would not be at all surprising if repeated use induced the chronic condition 